Post by WingsofCrystal on Apr 10, 2018 14:46:45 GMT
Alzheimer's gene neutralised in human brain cells for the first time
9 April 2018 • 8:05pm
Scientists have claimed an important breakthrough in the battle against Alzheimer’s after neutralising the most significant gene responsible for the disease for the first time.
A team in California successfully identified the protein associated with the high-risk apoE4 gene and then managed to prevent it damaging human neuron cells.
The study could open the door to a potential new drug capable of halting the disease, however the researchers have urged caution because so far their compound has only been tried on collections of cells in a laboratory.
Having one copy of the apoE4 gene more than doubles a person’s likelihood of developing Alzheimer’s disease, whereas having two copies increases the risk 12-fold.
Previous studies have indicated that roughly one in four people carry the gene.
In human neurons, misshapen apoE4 protein cannot function properly and is broken down into disease-causing fragments in the cells.
This results in several of the problems commonly found in Alzheimer’s disease, which affects 7.1 per cent of Britons above the age of 65, including the accumulation of protein tau and amyloid peptides.
The team at Gladstones Institutes set out to establish whether the presence of the protein was causing the damage, or whether a lack of it was to blame.
Using stem cell technology, they created neurons from skin cells donated by Alzheimer’s patients with two copies of the apoE4 gene.
By comparing the cells with those which did not produce an apoE protein they concluded that it was the the mere presence of the apoE4 protein was causing brain damage.
They then applied a genetic “structure corrector”, which eliminated the signs of Alzheimer’s.
The researchers are now working with the pharmaceutical industry to improve the compounds so they can be tested on human patients.
The experiment is particularly significant because it took place in human cells.
TO NETFLUENCE ~ OR NOT TO NETFLUENCE ~ THAT IS THE QUESTION!
MY GUESS IS YOUR CURIOSITY BROUGHT YOU TO OUR NEW SITE ~ WHERE ALL KEWL KATS WILL BE STOPPING IN!
CONTINUED FROM UFOCB I...
The DHS’s “Media Monitoring” plan, which was first reported by FedBizOpps.gov, would give the contracting company “24/7 access to a password protected, media influencer database, including journalists, editors, correspondents, social media influencers, bloggers etc.” in order to “identify any and all media coverage related to the Department of Homeland Security or a particular event.”
The database would be designed to monitor the public activities of media members and influencers by “location, beat and influencers,” the document says.
The chosen contractor should be able to “present contact details and any other information that could be relevant including publications this influencer writes for, and an overview of the previous coverage published by the influencer.”
Also, the contractor would have access to a password protected, mobile app that provides an “overview of search results in terms of online articles and social media conversations,” in several different languages such as Arabic, Chinese and Russian.
The request comes amid concerns regarding accuracy in media and the potential for U.S. elections and policy to be influenced via “fake news.”
The plan calls for the ability to track 290,000 news sources including online, print, broadcast and social media. Also, it would have the ability to track media coverage in over 100 languages, along with the “ability to create unlimited data tracking, statistical breakdown, and graphical analyses on ad-hoc basis.”
DHS spokesman Tyler Q. Houlton tweeted on Friday that the practice of monitoring the press is considered “standard.”
Hello Crystal et all. Good to see you continuing here.
Hello Phil! Glad to see you here!
Thank you. Just basically copied a whole thread over from the old forum to this new one. Wow, that took quite some time. Would have hated to see it being lost. Maybe some others could do the same with their favorite threads so that they won't get lost forever. That way we can keep them and are filling this brand new forum with content at the same time.
Post by WingsofCrystal on Apr 11, 2018 12:15:26 GMT
Good morning lovely people
MIT Tech Review
The next breathalyzer may be a chip implanted under your skin
Researchers have created a tiny, smart-watch-powered sensor to monitor your alcohol consumption.
by Rachel Metz 10 April 2018
Booze tracker: A group of engineers at the University of California, San Diego, created a prototype of a chip, meant to be injected under the skin, that could eventually be helpful for people who are in treatment for alcohol abuse. At just one millimeter across, it’s a fraction the size of a penny, which means it would be a lot less bulky than current alcohol-monitoring bracelets. Researchers say it can be more accurate than a breathalyzer test, and it’s less invasive than a blood test.
How it works: The chip includes tiny electrochemical sensors that measure, among other things, the amount of ethanol in the fluid between cells (which researchers say correlates with blood alcohol levels). It takes about three seconds to get a reading, and the chip is meant to draw power wirelessly from a smart watch or a patch.
Testing, testing: The researchers, who presented their work at a conference on Wednesday, haven’t tested the chip in people yet; they first tried it out in a lab in a substance meant to imitate human tissue. Testing in (tipsy?) live animals is next.
Post by WingsofCrystal on Apr 11, 2018 12:32:49 GMT
The World's Oldest Living Man Was Born Before We Even Had Radios
He's also very fond of candy.
11 APR 2018
At 112 years, Japanese supercentenarian Masazo Nonaka has just been recognised as the world's oldest man.
The new record holder was born on July 25, 1905 – the same year Teddy Roosevelt was inaugurated as the 26th president of the US.
The first radio broadcast happened in 1906.
The 112-year-old lives with his family, who manage a hot springs inn in Hokkaido.
"He needs a wheelchair to move but he is in good condition," Yuko Nonaka, his granddaughter, told AFP.
"He loves eating any kinds of sweets - Japanese or western style."
"He reads newspapers everyday and often soaks in the hot springs," she added.
That sounds like a pretty amazing way to live out your centennial teens, and that gummy smile pulls at our heart strings.
Even though Nonaka's longevity is an amazing feat, there are several people alive today who are even older - but all of them are women. The honour of the oldest living human goes to another Japanese person - Nabi Tajima, who is 117 years old.
When it comes to the science behind longevity, we're still not sure what makes some people live such long lives. But it's a pretty safe bet that none of these supercentenarians are likely to have been injecting the blood of teenagers to try and stay young.
But with an anti-ageing gene discovered in an Amish family, and scientists finally being able to reverse DNA ageing in mice, we might be closer than you think to slightly longer, and hopefully healthier lives.
That being said, maybe don't stop going to the gym just yet.
Post by WingsofCrystal on Apr 11, 2018 12:40:14 GMT
To Keep NASA's Golden Age Alive, We Need More Telescopes--but Far Less Expensive Ones
A focus on costly space telescopes is hurting the field
By Martin Elvis Scientific American April 2018 Issue
Starting around 50 years ago, astronomy began a winning streak of amazing discoveries. We found the cosmic microwave radiation left over from the big bang back in the 1960s, for instance, and in recent years we have identified thousands of planets orbiting distant stars. But the good times may be about to stop rolling. There is reason to fear that astronomy is ending its long run of lifting the veil on cosmic wonders.
Our early successes came from looking through new windows across a vast range of wavelengths invisible to the naked eye. The first radio, x-ray, ultraviolet and infrared telescopes were small, but everything we saw through them was new and mysterious. The next generation of telescopes leaped forward in capabilities, leading to the discoveries of neutron stars, black holes, dark matter, dark energy—the list goes on.
But this greater power came at a cost. Each new generation of telescopes carried a price tag several times higher than that of the one before. Today a single telescope can now take almost a full decade's worth of NASA's budget for “big astronomy.” A case in point is the James Webb Space Telescope, now scheduled for launch next year. Webb's price tag ballooned from what was originally supposed to be just about $1 billion to nearly $9 billion, crowding out nearly everything else. Without other major missions to fall back on, the only response to technical problems with Webb was to keep throwing more money at them.